The 1993 Phillies were the most fun team I have ever followed. I was nearing the end of my college years, and I vividly remember the insane night when me and 3 buddies celebrated a win at 4:30 **in the morning**, and the exact spot I was sitting when our hearts were broken with Joe Carter’s home run (I still look away when it comes up on highlight reels).

This week the catcher of that team, Darren Daulton, died after a battle with brain cancer. Newspapers have shared memories of “Dutch” and among the articles is one which reminds us of the surprising number of former Phillies who have passed away due to brain cancer (Tug McGraw, John Vukovich, and Johnny Oates). A revised 2013 article from the *Philadelphia Inquirer* analyzes the the unusual number of Phillies who have developed brain cancer, and contains many appropriate entry points for Statistics courses. Some highlights from the article:

- A comparison of the observed effect to random chance – here a professor of epidemiology summarizes: “You can’t rule out the possibility that it’s random bad luck.”
- A summary of plausible variables which could lead to elevated levels of exposure, such as artificial turf (which may have contained lead) or anabolic steroids.
- An analysis of the increase rate of brain cancer among Phillies – here we are told that the Phillies’ rate is “about 3.1 times as high” as the national rate. A confidence interval, along with an interpretation and associated cautions are also included.

Let’s explore that “3.1 times” statistic…time to break out the technology.

A few weeks back, I attended the BAPS (Beyond AP Statistics) workshop in Baltimore, as part of the Joint Statistics Meetings. Allan Rossman and Beth Chance shared ideas on using their applet collection to explore simulation (see my earlier post using the applets to Sample Stars) along with a “new” statistic we don’t often talk about in AP Stats – relative risk.

To start, I used the Analyzing 2-Way Tables applet and used the “sample data” feature. Here I attempted to use the same numbers quoted in the article:

The national rate was 9.8 cases per 100,000 adult males per year, while the rate in the former Phillies was 30.1 cases per 100,000 – about 3.1 times as high.

There are two issues here: first, to perform a simulation we need counts, so numbers like 9.9 and 30.1 just don’t play nice. I’ll use 10 and 30. Also, I wasn’t surprised that this site was not real happy with my using a population of 100,000 for simulation. Here, I am going with 1,000 for convenience and to make the computer processor gods happy – we can debate the appropriateness of this down the road.

The applet will then simulate the random assignment of the 2,000 subjects here to the two treatment groups (group A: being a Phillie, group B: not being a Phillie). How likely is it that we will observe 30 or more “successes” (which here represent those who develop brain cancer) in one of the two groups? In the applet, we can see how the “successes” have been randomly assigned from their original spots in the 2-way table to new groupings.

AT BAPS, Allan Rossman then explained how we can summarize these two groups using Relative Risk, which is listed under the “Statistic” menu on the applet. In general, relative risk is the proportion of success in one group divided by the proportion of success in a second group. If we have proportions in two groups which are equal, then the relative risk would be 1. We can then link to the newspaper article which claims a 3.1 “relative risk”, simulate many times with the applet (below we see the results of 10,001 simulations), and compare to the reported statistic.

According to the simulation, we should only expect to see a relative risk of 3 or above about 0.08% of the time – clearly an “unusual” result.

But the article does not claim a significant difference, and cautioned against doing so as a number of assumptions were made which could alter conditions. This would be an opportunity to discuss some of these design assumptions and how they could change the outcome.

Rest in Peace Dutch!